Gland inflammation plays an important role in the pathogenesis of fibrocystic prostatopathy and local adenomatosis against the background of the age-specific discoordination of the central and peripheral endocrine organs. The adenomatosis and inflammation provoke a number of clinical symptoms, which considerably inconvenience patients causing a constant psychological and emotional stress. Chronic growth of active catecholamine concentration (CA) and adrenal cortex hormones aggravate the age-dependent hormonal misbalance and reduce the functional activity of immunocompetent tissue, monocyte-phagocyte system and neutrophilocytes, which in its turn reduces the nonspecific body resistance. One of the indicators of the functional condition of a sympathoadrenal system is the CA content in erythrocytes; and one of the elements of the nonspecific body resistance are the nonenzymatic cationic proteins (NCP) of neutrophilocytes, which determine to a large extent their bactericide function. They can be also classified as signal-regulatory peptides.

This research consisted of two parts: morphological and clinical. The first part of the research included the histological and morphological evaluation of the structural changes in 20 prostate glands obtained from dead persons aged between 50 and 70 years, who suffered from different pathologies and according to anamnesis (medical report data), such associated diseases as nonmalignant hyperplasia of prostate gland (NHPG) and NHPG complicated by chronic prostatitis (CP). The clinical part was aimed at determining the NCP content in blood neutrophilocytes and CA concentration in erythrocytes, followed by calculating an average cytochemical coefficient (ACC) in 28 patients with NHPG, including the 8 patients with CP. The cytochemical research methods used for the evaluation, were adjusted to the age group of the dead material donors.

In the majority of cases, histological changes in prostate gland with NHPG involved stromal hyperplasia with the overgrowth of fibrous tissue and new growth in blood vessels, or complete hyperplasia with both proliferative glandular and stromal components. Moreover, the average area of the glandular tissue was 29,9 ± 4,7 % in the central part and 32,3 ± 4,9 % in the peripheral part, connective tissue - 43,7 ± 5,5 % and 48,6 ± 5,7 %, muscles - 26,4±4,0% and 19,4 ± 3,8 % correspondingly. Comparing the obtained data with the specific tissue volume in a healthy prostate gland, we can see that under the conditions of NHPG, grows mainly the connective tissue in peripheral part; moreover, its area increases by 23,6 ± 1,3 %. The biggest changes in the structure of prostate gland were observed in persons who experienced much stress, viral infections, chronic inflammatory processes and excessive allergen challenges during their life. A similar trend was revealed during the histochemical analysis. For example, the maximal reduction of the ACC in NCP level till 0,95 ± 0,06 (normal value 1,58 ± 0,03) and its growth till 2,17 ± 0,012 in CA content (normal value 1,76 ± 0,02) were observed in patients with long-standing NHPG complicated by CP.

To sum up, the results of the conducted research prove that degree of the structural changes in prostate gland with NHPG, is considerably influenced by the level of nonspecific body resistance, and activity of sympathoadrenal system, which should be taken into account during the treatment and prevention of this pathology.

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The work was submitted to international scientific conference «Fundamental research», (Israel, Tel Aviv), 10-17 April, 2010, came to the editorial office on 04.04.2010.