The Research´s Aim

It is necessary to be given the HDF efficiency general clinical assessment with kidneys´ functional state dynamics study at the patients´ HFNS severe form, having complicated by the ARF. 

 The Research´s Material and Methods

The 65 HFNS diseased persons with the ARF at the age of from 19 up to 60 years, whom, the HDF was used by the indications in the «online plus» regime, had been made up the researched group.

So, the HDF procedures have been carried out at the 4008S devices of the «Fresenius» firm with the «Fresenius F 605» hemodyafilters application.

The ARF clinical and the traditional biochemical parameters have already been included into the efficiency assessment. The kidneys´ function ultrasonic research with the blood circulation, the blood flow and its velocity parameters definition in the renal vessels has been carried out. The β - microalbumin has already been defined in the dynamics in the blood and in the urine; the microcirculation state has been estimated.

The Received Results. The HDF medical treatment adecuacy, according to the AFR usual clinical and the biochemical parameters, has already been achieved at all the patients (e.g. the urea, the creatinine, the electrolytic balance, the β - microalbumin, the acid - based homeostasis, the lipids peroxidation, the microcirculation indices and the others). By the renal ultrasonic research, the quite positive dynamics has been revealed. So, the before increased kidneys volume (e.g. 303,7 ± 13,2 cm3-262,3 ± 8,2 cm3; р < 0,05) the pyramids cross - section (e.g. (1,45 ± 0,04 сm2- 0,83 ± 0,04 сm2; р < 0,01), the bast layer echogenicity (e.g. 27,2 ± 0,08-22,1 ± 0,6 standard units; р < 0,01) have been statistically and significantly decreased.

The blood circulation and the blood flow, its velocity all the parameters in the kidneys have already considerably been improved (e.g. the blood flow systolic rate: 50,8 ± 2,5-58,8 ± 2,2 cm/s; р < 0,05; the blood flow diastoliс rate: 22,1 ± 0,4- 24,2 ± 0,2 cm/s; р < 0,05; the blood flow average rate 15,0 ± 0,5-29,4 ± 1,2 cm/s; р < 0,01; the blood flow volume rate 161,7 ± 8,6-216 ± 8,8; р < 0,01).

The Conclusions

The substitutive renal therapy carrying out at the HFNS patients with the ARF hemodyafiltration in the «on-line plus» regime is being exerted the expressed clinical effect with the quick biochemical parameters stabilization and with the kidneys´ functional state restoration.