The present research has been carried out on the «Wistar» line 30 rats of the both sex, at the age of 5-6 months. The animals have been distributed into the groups (e.g. n = 10): the control 1 (e.g. the animals, having received the physiological solution, as «the placebo»); the control 2 (e.g. the animals with the immune stress, having induced by the Рseudomonas aeruginosa lypopoly-saccharide (LPS) intraperitoneal introduction in the dose of 100 mkg/kg); the experimental group (e.g. the animals with the immune stress, having received the phenibut intraperitoneally in the dose of 25 mg/kg during 120 hours or 5 days). The latex test has been used for the phenibut influence study upon the neutrophils´ phagocytal activity of the peripheric blood; the phagocytal index (PHI) and the phagocytal number (PHN) have already been defined.

As it can be seen from the results, having presented in the Table 1, the LPS - induced immune stress formation is being accompanied by the phagocytal number and the phagocytal index increase more, than for 30 %, in comparison with the control 1 (e.g. р < 0,05). The neutrophils´ phagocytal activity restoration is being observed, under the animals´ phenibut influence with the immune stress in the experimental group: the indices, having reflected the phagocytosis intensity (PHI) and the cells´ number, having taken their part in the phagocytosis (PHY), are being decreased (e.g. р < 0,05), having achieved the background values in the control 1.

Table 1. The Phenibut Influence upon the Phagocytosis Indices on the LPS - Induced Immune Stress Model

The Experimental Groups	The Control 1: «placebo»	The Control 2: LPS. Рseudomonas aeruginosa (100 mgk/kg)	The Test: The Phenibut (25 mg/kg) + LPS. Рseudomonas aeruginosa (100 mgk/kg)
Phagocytal Index, %	55,9 ± 3,1	72,9 ± 3,6∆	59,4 ± 3,6*
The Phagocytal Number	4,5 ± 0,2	6,7 ± 0,3∆	4,0 ± 0,3*

The Reliability Degree, Concerning the Control 1 - ∆ - p < 0,05; the Control 2 - * - p < 0,05.

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Thus, the results, having received during the experimental work, are being testified on the phenibut ability to be removed the immune system non - specific component disorders, having appeared under the LPS - induced immune stress conditions.

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The work was submitted to international scientific conference «The Experimental and Clinical Medicine Contemporary Challenges», (Thailand), 20-30 December, 2009, came to the editorial office оn 09.11.2009.