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Home / Issues / № 2, 2011

THE TEENAGERS’ CYTOGENETIC HOMEOSTASIS PECULIARITIES AND SPECIAL FEATURES UNDER THE ECOLOGICAL ENVIRONMENT PRESENT – DAY CONDITIONS
Boldin V.E., Khrenkova V.V., Abakumova L.V., Soboleva E.V.
It is quite known, that the genetic homeostasis disorders symptoms, such as the micronuclei and the other nuclear anomalies, having revealed by the micro-nuclear test, are the non-specific human organism reaction upon the various and the diverse (e.g. toxic, ecological and stress) influences. The cytogenetic homeostasis evaluation has been carried out at the 118 lyceum pupils at the age of the 13-15 years, having learned at the «Classical» №1 lyceum MOU in the Rostov-on-Don town.

The buccal epithelium cells research by means of the micro-nuclear test (e.g. Zhuleva and et. al., 1996) has been discovered some quantity nuclei with the nuclear disorders presence at all the examined and the tested ones: by the micro-nuclei, by the invaginations, by the «tails», by the double nuclei, by the constrictions. Thus, the lyceum pupils´ cytogenetic homeostasis research results have already been presented in the Table 1.

The nuclear disorders relative quantity has been varied from 1 % up to 27 %, having made up in average 6,907 ± 0,404. The invaginations and the constrictions quantity from them has been varied in the ranges from 0 up to 8 %, having made up in average 1,746 ± 0,152 and 0,983 ± 0,123 correspondingly, the double nuclei quantity - from 0 up to 6 % (e.g. 1,364 ± 0,127), the micronuclei - from 0 up to 9 % (e.g. 0,881 ± 0,133) and the «tailing» nuclei - from 0 up to 13 % (e.g. 1,932 ± 0,180).

Table 1. The Nuclear Disorders Relative Quantity in the Lyceum Pupils´ Buccal Epithelium Cells (%)

 

N

M ± m

Minimum

Maximum

The nuclear disorders

118

6,907± 0,404

1

27

The constrictions

118

0,983 ± 0,123

0

8

The invaginations

118

1,746 ± 0,152

0

8

The double nuclei

118

1,364 ± 0,127

0

6

The micro-nuclei

118

0,881 ± 0,133

0

9

The «tailing» nuclei

118

1,932 ± 0,180

0

13


The «tailing» nuclei (e.g. 28 %) have been prevailed at the examined and the tested lyceum pupils´, the invaginations (e.g. 25 %), the double nuclei have been made up 20 %, the constrictions -14 %, the micro-nuclei - 13 %.

Thus, it is quite evidently, that the nuclear disorders maximum quantity have been made up the invaginations and the «tailing» nuclei.

So, the correlation analysis has been carried out by us for the purpose of the possible connections revealing among the lyceum pupils´ psycho-physiological characteristics and the cytogenetic homeostasis level by means of the Spearman correlation rank coefficient. The final and the obtained results have been presented in the Tables 2 and 3.

As it can be seen from the Tables, the correlation analysis has already been revealed the reliable moderate positive connection presence between the school anxiety level and the buccal epithelial cells relative number with the micronuclei. So, the connections between the FMA profile characteristics and the cytogenetic homeostasis indices have not already been discovered.

Table 2. The School Anxiety Level and the Lyceum Pupils´ Cytogenetic Homeostasis Indices Correlation

 

N

R (Spearman)

t(N - 2)

p

The constrictions & the school anxiety

65

-0,258633

-2,12514

0,037503

The invaginations & the school anxiety

65

-0,067785

-0,53926

0,591606

The double nuclei & the school anxiety

65

0,051745

0,41127

0,682273

The micro-nuclei & the school anxiety

65

0,291288

2,41683

0,018564

The «tailing» nuclei & the school anxiety

65

-0,098354

-0,78447

0,435706

The nuclear disorders & the school anxiety

65

-0,029021

-0,23044

0,818496

Table 3. The FMA Profile and the Cytogenetic Homeostasis Indices Correlation

 

N

R (Spearman)

t(N - 2)

p

The constrictions & FMA

104

0,090375

0,916492

0,361571

The invaginations & FMA

104

0,025098

0,253561

0,800345

The double nuclei & FMA

104

-0,064601

-0,653803

0,514710

The micro-nuclei & FMA

104

-0,082854

-0,839674

0,403055

The «tailing» nuclei & FMA

104

-0,048351

-0,488895

0,625966

The nuclear disorders & FMA

104

-0,021028

-0,212424

0,832200

As the formation, that is the micro-nuclei in the cells are being associated with the chromosomal or even the genomic disorders (e.g. Schmid W.,1975; Novitczky V.V. and et al., 1995), then the similar connection revealing between the cytogenetic indices and the school anxiety level is being indicated upon the development and the measures application necessary, having directed at the lyceum pupils´ way of the life and the activity optimization, in particular - having differed from the others by the school anxiety high level, cytogenetic homeostasis of which is, apparently, the most vulnerable one.


The work was submitted to International Scientific Conference «The Experimental and Clinical Medicine Contemporary Challenges», Thailand, 20-28 February, 2010, came to the editorial office on 25.12.2009.


Bibliographic reference

Boldin V.E., Khrenkova V.V., Abakumova L.V., Soboleva E.V. THE TEENAGERS’ CYTOGENETIC HOMEOSTASIS PECULIARITIES AND SPECIAL FEATURES UNDER THE ECOLOGICAL ENVIRONMENT PRESENT – DAY CONDITIONS. International Journal Of Applied And Fundamental Research. – 2011. – № 2 –
URL: www.science-sd.com/389-23516 (04.12.2021).