Introduction. The glutamic acid is involved in the regulation of long-term and short-term memory, displays nootropic properties [4]. The pharmacologists of Volgograd in cooperation with the chem-ists of the Russian State Pedagogical University in the name of A.I. Gertsen, have worked out a new derivative of the glutamic acid with the laboratory code number of RGPU-135, which possesses the marked psychotropic action and low toxicity [2, 5]. The objective of the research is the comparative study of the antiamnestic properties of the glutamic acid and its new phenylic derivative RGPU-135. Materials and methods. The experiments have been carried out on the white outbreeded male rats (180-200g), kept in standard vivarium conditions. There were carried out 2 series of experiments: 1) the study of the influence of the substances on the conditioning and the dynamics of the reflex ex-tinction with the course of time in the test of “conditioned passive avoidance response” (CPAR) [1]; 2) the study of the influence of the substances on the intensity of the CPAR amnesia caused by the maximal electric shock (MES) [5]. In the 1st series of the experiments the verification of the maintenance of the reflex in CPAR was carried out in 24 hours, 7, 14, and 30 days after the training [1]. In the 2nd series MES was reproduced directly after the conditioning of the CPAR by applying the electric stimulus through the corneal electrodes (50Hz, 150mA, 0,2s); the CPAR was repro-duced in 24 hours after the MES [5]. L-glutamic acid (Panreac (Barcelona, España)) and the RGPU-135 compound were introduced intragastricly into animals once in 2% amylaceous mucus 1 hour before the conditioning of the CPAR in the effective doses – 200mg/kg [6] and 26mg/kg [2], re-spectively. The control animals received 2% amylaceous mucus in the equivalent volume. The sta-tistical treatment of the results: the Kruskal-Wallis analysis, the Newman-Keuls and Fisher criteri-ons. Results and discussion. The glutamic acid and the RGPU-135 compound enhanced the condition-ing and maintenance of the CPAR reflex in the dynamics of a 30-day research: they increased the latent period (LP) of the first approach to the dark aisle, reduced the quantity of approaches there and the quantity of animals (in the group) having visited the following aisle on the skill reproduction stage (statistically significant change of the LP of the first approach was on the 14th and the 30th day after the training). The RGPU-135 compound statistically significantly to a greater extent than the glutamic acid increased the LP of the first approach into the dark aisle and the quantity of animals (in the group) having visited it in the reproductions of the reflex in 7 and 14 days after the training. The RGPU-135 compound and the glutamic acid enhanced the maintenance of the CPAR reflex of animals: on the stage of the reflex reproduction in 24 hours after the MES. In the groups, which were receiving the glutamic acid and the RGPU-135 compound 75% and 87,5% of rats were trained, respectively, which was statistically significantly more than in the control group – 65% of animals. The enumerated effects of the glutamic acid and the RGPU-135 compound show their abil-ity to display the antiamnestic properties – to perform nootropic action, according to the intensity of which the RGPU-135 compound statistically significantly surpassed the glutamic acid. Conclusion. The new phenylic derivative of the glutamic acid RGPU-135 displays antiamnestic properties, according to the intensity of which it surpasses the glutamic acid.

Introduction. The glutamic acid is involved in the regulation of long-term and short-term memory, displays nootropic properties [4]. The pharmacologists of Volgograd in cooperation with the chemists of the Russian State Pedagogical University in the name of A.I. Gertsen, have worked out a new derivative of the glutamic acid with the laboratory code number of RGPU-135, which possesses the marked psychotropic action and low toxicity [2, 5]. The objective of the research is the comparative study of the antiamnestic properties of the glutamic acid and its new phenylic derivative RGPU-135.

Materials and methods. The experiments have been carried out on the white outbreeded male rats (180-200g), kept in standard vivarium conditions. There were carried out 2 series of experiments: 1) the study of the influence of the substances on the conditioning and the dynamics of the reflex extinction with the course of time in the test of "conditioned passive avoidance response" (CPAR) [1]; 2) the study of the influence of the substances on the intensity of the CPAR amnesia caused by the maximal electric shock (MES) [5]. In the 1^st series of the experiments the verification of the maintenance of the reflex in CPAR was carried out in 24 hours, 7, 14, and 30 days after the training [1]. In the 2^nd series MES was reproduced directly after the conditioning of the CPAR by applying the electric stimulus through the corneal electrodes (50Hz, 150mA, 0,2s); the CPAR was reproduced in 24 hours after the MES [5]. L-glutamic acid (Panreac (Barcelona, España)) and the RGPU-135 compound were introduced intragastricly into animals once in 2% amylaceous mucus 1 hour before the conditioning of the CPAR in the effective doses - 200mg/kg [6] and 26mg/kg [2], respectively. The control animals received 2% amylaceous mucus in the equivalent volume. The statistical treatment of the results: the Kruskal-Wallis analysis, the Newman-Keuls and Fisher criterions.

Results and discussion. The glutamic acid and the RGPU-135 compound enhanced the conditioning and maintenance of the CPAR reflex in the dynamics of a 30-day research: they increased the latent period (LP) of the first approach to the dark aisle, reduced the quantity of approaches there and the quantity of animals (in the group) having visited the following aisle on the skill reproduction stage (statistically significant change of the LP of the first approach was on the 14^th and the 30^th day after the training). The RGPU-135 compound statistically significantly to a greater extent than the glutamic acid increased the LP of the first approach into the dark aisle and the quantity of animals (in the group) having visited it in the reproductions of the reflex in 7 and 14 days after the training. The RGPU-135 compound and the glutamic acid enhanced the maintenance of the CPAR reflex of animals: on the stage of the reflex reproduction in 24 hours after the MES. In the groups, which were receiving the glutamic acid and the RGPU-135 compound 75% and 87,5% of rats were trained, respectively, which was statistically significantly more than in the control group - 65% of animals. The enumerated effects of the glutamic acid and the RGPU-135 compound show their ability to display the antiamnestic properties - to perform nootropic action, according to the intensity of which the RGPU-135 compound statistically significantly surpassed the glutamic acid.

Conclusion. The new phenylic derivative of the glutamic acid RGPU-135 displays antiamnestic properties, according to the intensity of which it surpasses the glutamic acid.

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