Key words: artichoke prickly, extract of medicinal plant, nanoparticles, sodium carboxymethylcellulose, nanocomposites.

Topicality: In the development of modern nanotechnology, a significant role is played by studies of nanoparticles obtained from extracts of medicinal plants with the help of solutions of metal salts. This is due to the wide range of possibilities for their practical application, in which the specific properties of both the nanoparticles obtained from the extracts of medicinal plants and the materials modified by them are used.

Of great interest is the study of plant objects that are used as food and at the same time may contain biologically active substances exhibiting hepatoprotective and choleretic activity. The number of such objects should be attributed to the artichoke prickly (Cynara scolymus L.), which belong to the aster family (Asleraceae). Cynara scolymus L. is used as a food product and medicinal plant especially in Europe, South America and other countries of the world. Its nutritional value is explained by the presence in the tissues of such biologically active substances as polyphenolic compounds, polysaccharides, organic acids, etc.

Materials and methods of research: In this regard, the study of artichoke prickly and the possibility of obtaining nanoparticles and drugs based on them is an actual problem for pharmaceutical science and practice. At the same time, it should be noted that in some European and other countries of the world, over the last 10-15 years, researchers have begun to deal with nanoparticles and the creation of nano-drugs based on them. However, in this area in Uzbekistan they are just beginning to be engaged, although it has a great future in the field of pharmaceuticals and medicine.

Results and discussion: An important characteristic of the raw material is its commodity moisture, at which it is stored in dry rooms without deterioration, as well as its ash content (ash is insoluble in hydrochloric acid). Experimental data showed that for cultivation in the region of Central Asia, the moisture content of the dry extract of medicinal plant Cynara scolymus L obtained from the leaves was 8-12 ± 0.5%, and the ash content was 7-10 ± 0.5%, hydrochloric acid insoluble 2.0- 2.2% ± 0.1, organic impurities 0.6-0.7 ± 0.04%, mineral impurities 0.6 ± 0.03%. The norm of organic and mineral impurities in the composition of the raw materials is considered appropriate no more than 1%. The content of extractive substances in the leaves of Cynara scolymus L. for 70% ethyl alcohol was 23.7 ± 0.5%.

The phytochemical study of artichoke prickly leaves cultivated in Uzbekistan was carried out with the aim of creating an effective nano-drug with high pharmacological action. A qualitative analysis of flavanoids found in the leaves of artichoke prickly showed that for the extract obtained with 70% ethyl alcohol is: rutin - 0.76; quercetin - 0.88; luteolin - 0.91; cynaroside - 0.83; scutelarin - 0.90; hyperoside - 0.78.

Thus, Cynara scolymus L. cultivated in the conditions of the Republic of Uzbekistan corresponds to the standard indicators required for the creation of nano-drugs. The extracts contain such biologically active substances as phenolic compounds, tannins, vitamins, amino acids, fatty acids, and carbohydrates.

To obtain a nanoparticle from artichoke prickly, an extract from the leaves of Cynara scolymus L. was prepared. An extract was prepared with 70% ethyl alcohol in the ratio of Cynara scolymus L.: ethyl alcohol = 1:10. In the obtained extracts from artichoke prickly over time, aggregation occurs. The natural polysaccharide sodium carboxymethylcellulose (Na-CMC) can be used to enhance aggregative stability. The introduction of Na-CMC significantly prevents aggregation and reduces the average size of nanoparticles.

By mixing solutions of artichoke prickly extracts with a nanoparticle with solutions of sodium carboxymethylcellulose in various volume ratios, a nanocomposite was obtained in which the nanoparticles are stabilized by the polysaccharide Na-CMC. With increasing concentration of metal salt, an increase in the size of nanoparticles is observed. pH of nanocomposites, depending on the concentration of metal salts is in the range of 5.5 - 6.5.

Conclusion: Thus, the synthesis of nanoparticles from an extract of a medicinal plant artichoke prickly with the introduction of metal salts was carried out. By varying the concentration of polysaccharide sodium carboxymethylcellulose, aggregatively stable nanocomposites were obtained.